Özet:

Background: Bronchopulmonary dysplasia (BPD), necrotizing enterocolitis (NEC), retinopathy of prematurity (ROP), intraventricular hemorrhage (IVH) and long term negative neurodevelopmental outcomes. are associated with PDA. The aim of this study was to determine the frequency of hemodynamically significant (hs) PDA and the demographic and clinical characteristics of very low birth weight (VLBW) premature infants. Material and Methods: We retrospectively evaluated the medical records of VLBW preterm infants with a gestational age <30 weeks between January 2013 and December 2016. Infants with major congenital anomalies and those who were death before the first echocardiographic evaluation were excluded from the study. Eligible infants were divided into two groups, including group I: with hsPDA and group II: without hsPDA. Demographic and clinical characteristics of infants were recorded and compared between the groups. Results: A total of 602 VLBW infans were included. 257 (42.7%) infants had hsPDA, and 11 (1.8%) infants with hsPDA had PDA ligation due to being unresponsive to medical treatment. Gestational age and birth weight were significantly lower in infants with hsPDA. RDS, late neonatal sepsis, ROP, IVH (grade ≥3), moderate-severe BPD rates were significantly higher; invasive and non-invasive respiratory support, duration of additional oxygen requirement, time to complete enteral feeding, and duration of hospital stay were significantly longer in infants with hs PDA (p <0.05). Conclusion: In our study, the rate of hsPDA was found to be 42.7% in VLBW infants. The rates of hsPDA can vary due to different clinical approaches among the units. Although, it is clearly associated with long and short-term morbidities, proper interventions in time should be aimed at minimizing morbidities.

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