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  Citation Number 1
 Views 11
 Downloands 2
Albümin Globulin Oranının Küçük Hücreli Akciğer Kanserinde Prognostik Önemi
2019
Journal:  
Ankara Medical Journal
Author:  
Abstract:

Giriş: İnflamasyon kanser gelişimini kolaylaştırmanın yanı sıra birçok kanser tipinde kötü prognozla da ilişkilidir. Albümin ve globülin inflamasyonu yansıtan belirteçlerden ikisidir. Albüminin özellikle inflamasyon dışı birçok nedenden etkilenebileceği için albümin globülin oranının inflamasyonu yansıtmada daha başarılı olacağı gösterilmiştir. Biz bu çalışmada albümin globülin oranın (AGO) küçük hücreli akciğer kanserinde (KHAK) prognostik öneminin belirlenmesi ve diğer inflamatuar parametrelerle ilişkisinin saptanmasını amaçladık. Materyal ve Metot: Retrospektif olarak 2014-2018 yılları arasından tanı almış KHAK hastaları çalışmaya dâhil edildi. Tanı anındaki albümin globüline bölünerek AGO bulundu. Medyan değer olan 1,2 AGO için eşik değer olarak kabul edildi. Bulgular: Toplam 81 hasta çalışmaya dâhil edildi. Hastaların %40,30’ü AGO < 1,2 olarak saptanırken, % 59,30’ünün ise AGO ≥ 1,2 olarak bulundu. Her iki grup hasta özellikleri açısından benzerdi. AGO ile nötrofil lenfosit oranı ve platelet lenfosit oranı arasında istatistiksel anlamlı ters korelasyon saptandı. AGO ≥ 1,2 olan grupta hem progresyonsuz sağkalım hem de genel sağkalım istatistiksel olarak daha uzundu. Sonuç: AGO hem kolay uygulanabilir hem de ucuz bir belirteç olması nedeniyle KHAK’de prognostik belirteç olarak kullanılabilir.

Keywords:

The Prognostic Importance of the Album's Globulin Rate in Small Cell Lung Cancer
2019
Author:  
Abstract:

Introduction: Inflammation is associated with poor prognosis in many types of cancer, as well as facilitating the development of cancer. It is two of the indicators that reflect the inflammation of albumin and globulin. As the album may be affected by many non-inflammatory causes, the album’s globulin rate has been shown to be more successful in reflecting inflammation. In this study, we aimed at determining the prognostic importance of albumin globulin rate (AGO) in small-cell lungs cancer (CHA) and determining its relationship with other inflammatory parameters. Materials and Methods: The KHAK patients diagnosed retrospectively between 2014-2018 were included in the study. The album was divided into the globule at the moment of diagnosis. The median value of 1.2 AGO was considered as the margin value. A total of 81 patients were involved in the study. 40.30% of patients were identified as AGO < 1.2 and 59.30% were identified as AGO ≥ 1.2. Both groups were similar in terms of the characteristics of the patient. A statistically significant reverse correlation between AGO and the neutrophil lymphocytes rate and the platelet lymphocytes rate was established. In the group with AGO ≥ 1.2 both progressive survival and overall survival were statistically longer. Result: AGO can be used as a prognostic indicator in KHAK because it is both easy to apply and a cheap indicator.

Keywords:

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Ankara Medical Journal

Field :   Sağlık Bilimleri

Journal Type :   Uluslararası

Metrics
Article : 689
Cite : 1.639
2023 Impact : 0.136
Ankara Medical Journal