Özet:

Aim. Atherosclerosis is regarded as a chronic inflammatory disease developing in response to injury in the vessel wall. Inflammation plays a key role in the development of atherosclerosis. Interleukin- 1α (IL-1α) has a critical role on regulation of proinflammation. The aim the study was to assess the relationship between the IL-1α -889 C/T polymorphism and the atherosclerosis. Method. The study population was composed of 117 patients (Group I) and 117 healthy adults (Group II). Genomic DNA of case and control was extracted from blood leukocytes. IL-1α genotype were further confirmed by direct sequencing of randomly selected samples. Results. 78 male and 39 female individuals in the group I, 49 men and 68 women in Group II. The average age of individuals in the Group I 61.06, the average age of individuals in the Group II 59.47 years old. The Group I 43 and the Group II were detected in 28 individuals with high cholesterol(total cholesterol>200 mg/dL). 62 individuals in the Group I and 51 individuals in the Group II was smoking. The Group I 81 individuals with high blood pressure(systolic blood pressure>140 mmHg and / or diastolic blood pressure>90 mmHg), 42 individuals with diabetes, the Group II 32 individuals with high blood pressure, diabetes was found 41 individuals. In the atherosclerotic coronary artery patients of %54.70 individuals carrying the CC genotype, %35.04 individuals carrying the CT genotype and %10.25 individuals carrying the TT genotype constitutes. In the healty control group, %59.82 individuals carrying the CC genotype, %30.76 individuals carrying CT genotype and %9.40 individuals carrying TT genotype. IL-1α polymorphism of C allele frequency is %75.21 in the Group II and %72.22 in the Group I. T allele freguency distribution of %24.78 in the Group II and %27.77 in the Group I. Conclusion. Those with coronary artery disease group between the Group II age, sex distribution, hypertension and hypercholesterolemia were found statistically significant relationship. There was no statistically significant difference between groups according to the IL-1α-889 C/T gene polymorphism.

Anahtar Kelimeler: