Abstract:

Today, alcohol intake is a significant factor in many diseases primarily digestive system disorders. Despite dopamine agonists for helping to heal on alcohol-induced damages was known, the effects of bupropion on ethanol-induced varying biochemical parameters were not clarified completely. This study was conducted to assess the effects of bupropion on some changing biochemical parameters due to ethanol treatment. Rats were administered with 56% ethanol twice a week for four weeks and then bupropion was orally administered in doses of 30 and 60 mg/kg for 7 days. At the end of the study, it was found that bupropion reversed the values of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), urea, creatinine, total protein, and glucose changed by ethanol. Study findings proved that bupropion improved effectively the changed biochemical parameters due to alcohol administration.