Abstract:

Goal: Tuberculosis (TB), which continues to be a global health problem, is influenced by environmental factors and host genetic factors. This study was aimed at investigating the relationship between single nucleotid polymorphisms (single nucleotid polymorphism - SNP) in patients with tuberculosis in the -1478CA/del (rs33989964) and 1335G/C (rs11549428) in the exon-2 in the cytokine signal suppressor (SOCS)-1 gene promoter area with the tendency or resistance to tuberculosis. The study included 90 healthy blood donors as a control group with 90 TB patients isolated from the Mycobacterium tuberculosis complex in the culture of the clinical sample. For the determination of the SNPs studied, polymerase chain reaction and restriction piece length polymorphism methods were used. Results: The -1478CA/del SNP in the SOCS-1 gene promoter area is in the Hardy-Weinberg balance in the patient and healthy control group, while there is no meaningful relationship between the groups in terms of allel frequency (p=0.327) and genotype distribution (p=0.291). According to the 1335G/C SNP analysis found in the SOCS-1 gene exon-2 all of the patient and control group C alelium, no statistical assessment was made. Result: The study found no relationship between the SNPs found in the SOCS-1 gene and resistance or sensitivity to TB. This study should be understood that different polymorphisms may also occur on the SOCS-1 gene that needs to be investigated.

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