Özet:

Simultaneous insulin and C-peptide levels obtained during oral glucose tolerance test (OGTT), are compared in three groups of patients: first, with normal glucose tolerance; second, with inappropriate glucose tolerance and third with type II Diabetes Mellitus (DM). Also these three groups were compared by and indicator of Homeostasis Model Assessment Insulin Resistance Index (HOMA) to find out any significant difference. 165 patients (108 female, 57 male) between ages of 20 and 81, who undergo OGTT at Ankara Numune Hospital were included in the study. These patients were classified according to the criteria of the National Diabetes Data Group as one group with normal glucose tolerance, one with inappropriate glucose tolerance, and another with type II DM. These three groups were compared via insulin and C-peptide levels and HOMA indexes. Insulin levels at 30.’ of the groups with inappropriate glucose tolerance and type II DM were found to be lower than the group with normal glucose tolerance. These results can be explained by the first phase insulin secretion inefficiency in these two groups. Insulin levels at 180.’ and 240.’ in the group with inappropriate glucose tolerance and those at 120.’, 180.’, 240.’ and 300.’ in the group with type II DM were higher than the group with normal glucose tolerance. Also the insulin level at 180.’ in the group with type II DM was found elevated when compared with the group with inappropriate glucose tolerance and type II DM is overcame by the increment of pancreatic insulin secretion in the second phase. The comparisons using the HOMA index has shown that the most remarkable difference between the groups was at 180.’ levels. The values at 120.’ and 240.’ were also found to be significant.

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