Özet:

Goal: Gilbert syndrome is a benign disease characterized by increased indirect bilirubin levels, seen with repeated light yellowness. The aim of this study is to investigate the effects of increased levels of bilirubin on red crop distribution width (RDW), average thrombocyte volume (MPV), neutrophil/lenphocyte ratio (NLR), platelet/lenphocyte ratio (PLR) and other hematological parameters. Method: A total of 1190 young men between the ages of 20 and 28 who apply for entry examinations were taken to work. In the framework of the entry examinations, detailed anamnesis, detailed physical examination, hematological and biochemical parameters, all abdominal ultrasounds were performed. Of the 774 patients that meet the criteria, 63 patients with no pathological outcome except the indirect bilirubin height were diagnosed with Gilbert syndrome. As a control group, 70 patients were randomly selected among 711 patients. Statistical comparisons and correlation analyses were made. The findings: in the Gilbert syndrome group, RDW was 12,0 ± 1,1; MPV was 7,7 ± 0,7 fl; NLR was 2,23±1,07; PLR was 113,1±31,0. The RDW value of the control group was 11.8 ± 0.9 (p=0.153); MPV 8.2 ± 0.8 fl (p<0,001); NLR 1.84 ± 0.78 (p=0.026); PLR 102.6 ± 28.1 (p=0.044) In comparisons, there was no difference between the two groups in RDW; in Gilbert syndrome, the MPV control group was statistically significantly low, and the NLR and PLR were high. A significant negative correlation between the total bilirubin levels and the MPV and lymphocytes numbers was found (p<0,05). In the cardioprotective effect of Gilbert syndrome, changes in hematological parameters can play a role.