Abstract:

Aim: Neoadjuvant chemotherapy is used to increase tumor resection rates, prevent metastasis and prolong survival. It is not fully understood which factors are important in recurrence after surgery. In our study, the effects of neoadjuvant chemotherapy treatment duration, tumor histopathology, and biochemical values on postoperative recurrence in gastric cancer patients were investigated. Method: Our study included 61 patients who were diagnosed with locally advanced gastric cancer and underwent surgery after neoadjuvant chemotherapy. The duration of treatment with neoadjuvant, the number of pathological lymph nodes removed during surgery, preoperative albumin level, and postoperative carcinoembryonic antigen (CEA) values were compared and evaluated according to the recurrence status. Results: The mean age of our patients was 58.70±10.58 years. In patients who developed recurrence after surgery, the number of pathological lymph nodes removed during surgery and the postoperative CEA value was found to be statistically significantly higher (p <0.001, p=0.005, respectively), and high preoperative albumin levels reduced recurrence (HR=0.016). Conclusion: In our study, it was shown that preoperative albumin level and postoperative CEA value were associated with the development of recurrence after surgery in gastric cancer patients receiving neoadjuvant therapy.

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