Özet:

Gliosarcoma is a rare tumor of the central nervous system composed of glial and mesenchymal components. It is considered to be a glioblastoma variant according to the 2007 World Health Oranization (WHO) classification and often holding the cerebral hemispheres. Gliosarcomas are biphasic tumors that containing malignant glial and mesenchymal components. Immunohistochemistry is important to distinguish gliosarcoma and glioblastoma. Developmental mechanisms of gliosarcomas are not clear. It is considered that large part of gliosarcomas develop as de novo, and lesser part of them develop after resection and radiotherapy for glioblastome multiforme. Molecular genetic studies suggest that the two components of gliosarcoma origin of monoclonal precursor cells. In this study a case of gliosarcoma in 53 years old man who applied to emergency room with headache, is reported. We aimed to describe clinical, histopatological and immunohistochemical features of gliosarcoma and to discuss its pathogenetic mechanisims.

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