Özet:

The main goal of this review is to highlight the most recent findings about the regulation of apoptosis by BCL-2 family members. Apoptosis, a crucial biological mechanism, is a reaction to cellular stress or developmental stimuli. Impaired apoptosis is a major contributor to cancer formation and lowers the effectiveness of conventional cytotoxic therapy. Over the last ten years, researchers have heavily focused on understanding the pro- or anti-apoptotic activities of members of the B-cell lymphoma 2 (BCL-2) protein family and its significance in controlling carcinogenesis, apoptosis, and cellular reactions to anticancer treatment. The development of anticancer medications targeting apoptosis is currently receiving increasing attention because the inflammatory response brought on by apoptosis-induced cell death is extremely little. Additionally, it was investigated how BCL-2 family proteins control apoptosis. The promise of BCL-2 family proteins in cancer treatment is suggested by all of the research.

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