Özet:

Acute lymphoblastic leukemia (ALL) is the most common form of cancer in children, comprising approximately 30 percent of all childhood malignancies. Survival rates for ALL have improved dramatically since the 1980s, with current fi and-year overall survival rates estimated at greater than 80 percent. This improvement in survival is due to the treatment of a large number of children on sequential standardized research protocols. While the vast majority of children with ALL enjoy long-term survival/cure, the serious nature of the disease, as well as the aggressiveness of the treatment protocols have resulted in significant cant early and late treatment-related mortality. Much of the treatment-related mortality occurs during the fi rst year of ALL treatment, often during induction or shortly after that. Many long-term survivors of childhood cancer will also develop chronic physical or psychosocial problems as a result of their cancer or its therapy. The purpose of this paper is to review the early and late effects of ALL therapy

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