Abstract:

AIM The harmful effects of smoking on body are known to be caused by oxidative stress in tissues. With the many harmful substances in smoke it serve as a good model of free radical damage could be monitored. The agents preventing free radical induced oxidation, capable of trapping and stabilizing free radicals are called 'antioxidants". Resveratrol is a powerful antioxidant that has anti-inflammatory, analgesic and osteogenic effects. In this study we evaluated the effects of smoking and resveratrol on oxidative stress. MATERIAL VE METHOD For 4 weeks rats were inhalated cigarette smoke (6 cigarette/day) and after that time 20 mg/kg/day resveratrol was given via oral gavage during 28 days together with cigarette smoke. At the end of 8 weeks total exposure to cigarette smoke, rats were sacrified and bloods and tongue samples were collected. Biochemically serum and tissue total antioxidant / oxidant capacity (TAC / TOC) were evaluated. RESULTS There were no statistical difference between groups in terms of TAC and TOC serum. TAC tongue is higher in cigarette+resveratrol and cigarette groups. CONCLUSION In the experiment performed with 6 cigarettes per day for 8 weeks, toxic effect of cigarette induced antioxidant system in the organism to protect the body and that is more effective than antioxidant effect of resveratrol.

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