Abstract:

Objective: We aimed to compare the peripapillary retinal nerve fiber layer (pRNFL) and choroidal thickness in na­ive type 2 diabetic patients without diabetic retinopathy (DR) with healthy subjects. Methods: The study included newly diagnosed diabetic patients without DR and healthy control subjects. Hori­zontal plane scan of choroid was performed using en­hanced depth imaging (EDI) mode of spectral-domain optical coherence tomography (SD-OCT). The choroidal thickness was measured at the central fovea and at 1000 μm nasal and temporal from the center of the fovea. In addition, the same measurements were performed for pRNFL thickness. Results: The study included 28 eyes of the 28 newly di­agnosed with diabetic patients without DR and 28 eyes of the 28 healthy subjects. Age, gender, spherical equivalent refraction, best-corrected visual acuity, intraocular pres­sure and axial length were not difference between groups. The choroidal thickness of subfoveal and temporal areas were thinner in the naive DM group than that of control group (p = 0.04, p = 0.006, respectively.). In pRNFL analy­sis, average, nasal and superior temporal quadrants were significantly thinner in the newly diagnosed with DM than those of control group. There were no significant differ­ences in other pRNFL quadrants. Conclusion: When the data were analyzed, in addition to thinning of the choroid layer, it is possible to say that some thinning can be observed in the pRNFL particularly at the average, nasal and temporal superior quadrants in the patients newly diagnosed with DM without DR.

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