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Amaç: Disk hernisi ve spinal stenoz varlığında semptomların gelişebilmesi için sinir kökünde inflamasyon ve irritasyonun olması gerektiği belirtilmektedir. Bu çalışmada inflamatuar değişikliklerin hastalık patogenezinde yer aldığı belirtilen tek seviye lomber disk hernisi ve çok seviyeli lomber spinal stenoz hastalarında sistemik inflamasyonun belirteçleri olarak kabul edilen nötrofil lenfosit oranı ve trombosit lenfosit oranını kullanarak bu iki hastalık arasındaki inflamatuar farklılığı ortaya koymak amaçlandı. Gereç ve Yöntem: Tek seviye lomber disk hernisi tanısı almış 50 hasta (31 kadın, 19 erkek), lomber spinal stenoz tanısı almış 50 hasta (34 kadın, 16 erkek) ve 50 sağlıklı birey (33 kadın, 17 erkek) oluşan kontrol grubu olarak çalışmaya dahil edildi. Üç grubun tam kan değerleri retrospektif olarak hastane verilerinden kaydedildi. Bulgular: Gruplar arasında nötrofil lenfosit oranı ve trombosit lenfosit oranını değerleri açısından istatistiksel olarak anlamlı bir farklılık vardı (sırasıyla, p<0.001, p=0.003). Kontrol grubunun değerleri diğer gruplara göre daha düşük olarak saptandı. Ayrıca lomber spinal stenoz grubunda nötrofil lenfosit oranı değerlerinin daha yüksek olduğu ve lomber disk hernisi grubu ile de istatistiksel olarak anlamlı bir fark olduğu tespit edildi (p<0.001). Sonuç: Nötrofil lenfosit oranı ve trombosit lenfosit oranını değerleri sinir dokusunda ortaya çıkan inflamasyonu değerlendirmekte kolay uygulanabilen ve düşük maliyetli tam kan sayımı verilerinden hesaplanarak elde edilen yeni belirteçlerdir. Kompresyona uğrayan sinir dokusunun artıp artmadığını anlamakta nötrofil lenfosit oranı hekime kolaylık sağlayabilir.
Objective: It is stated that there must be inflammation and irritation in the nerve root in order to develop symptoms in the presence of disc herniation and spinal stenosis. In this study, it was aimed to reveal the inflammatory difference between these two diseases by using the neutrophil lymphocyte ratio and the platelet lymphocyte ratio which are accepted as markers of systemic inflammation in single level lumbar disc herniation and multi-level lumbar spinal stenosis patients. Methods: Fifty patients (31 female, 19 male) with a single lumbar disc herniation, 50 patients (34 female, 16 male) with lumbar spinal stenosis and 50 healthy controls (33 female, 17 male) were included in the study.The complete blood count of the three groups were recorded retrospectively from the hospital data. Results: There was a statistically significant difference between the groups in terms of the neutrophil lymphocyte ratio and platelet lymphocyte ratio (p <0.001, p = 0.003, respectively). The values of the control group were lower than the other groups. In addition, it was detected that the lumbar spinal stenosis group had higher neutrophil lymphocyte ratio and there was a statistically significant difference with the lumbar disc herniation group (p <0.001). Conclusion: Neutrophil lymphocyte ratio and platelet lymphocyte ratio are the new markers that can be easily applied to evaluate inflammation in nerve tissue and calculated from low-cost complete blood count data. The neutrophil lymphocyte ratio may be easier for the physician to understand whether the compressed nerve tissue increases.
Objective: It is stated that there must be inflammation and irritation in the nerve root in order to develop symptoms in the presence of disc herniation and spinal stenosis. In this study, it was aimed to reveal the inflammatory difference between these two diseases by using neutrophil lymphocyte ratio and platelet lymphocyte ratio which are accepted as markers of systemic inflammation in single level lumbar disc herniation and multi-level lumbar spinal stenosis patients. Methods: Fifty patients (31 female, 19 male) with a single lumbar disc herniation, 50 patients (34 female, 16 male) with lumbar spinal stenosis and 50 healthy controls (33 female, 17 male) was included in the study.The complete blood count of the three groups were recorded retrospectively from the hospital data. Results: There was a statistically significant difference between the groups in terms of neutrophil lymphocyte ratio and platelet lymphocyte ratio (p <0.001, p = 0.003, respectively). The values of the control group were lower than the other groups. In addition, it was detected that the lumbar spinal stenosis group had higher neutrophil lymphocyte ratio and there was a statistically significant difference with lumbar disc herniation group (p <0.001). Conclusion: Neutrophil lymphocyte ratio and platelet lymphocyte ratio are the new markers that can be easily applied to evaluate inflammation in nerve tissue and calculated from low-cost complete blood count data. The neutrophil lymphocyte ratio may be easier for the physician to understand whether the compressed nerve tissue increases.
Alan : Sağlık Bilimleri
Dergi Türü : Uluslararası
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