Özet:

Purpose: The staining of endothelial cells with specific markers such as CD34 and Factor VIII-Related Factor (vonWillebrand Factor) is a method used to detect angiogenesis of tumour. In this study, we aimed to evaluate the 3rd common type of gynecological cancer and fatal epithelial ovarian tumors, by using immunohistochemistry to investigate vascular surface density. Materials and methods: In this study, sexty patients who were operated at the SSK Aegean Maternity Hospital were evaluated. Ovarian specimens from women in follicular or luteal phases without ovarian pathology were investigated as a control group; specimens with borderline serous, borderline musinous, musinous adenocarsinoma, who had gone undergone reportoscopy were investigated as the study group (n= 10). Ovarian tissues were fixed in formaline and embedded in paraffin. Histological sections were immunostained with CD34 and vonWillebrand factor primary antibodies using indirect immunoperoxidase technique. Vascular surface densities in both study and control groups were evaluated using intercept grid. Data were evaluated statistically with using ANOVA test. Results: The average vascular surface density was not statistically different between the ovarium in follicular and in luteal phases. The average vascular surface density was significantly higher in both borderline and malign ovarian carcinoma than control group. In addition, the average vascular surface density was highest in the in musinous carcinoma. Conclusion: Angiogenesis plays a key role during follicular and luteal phases in normal menstrual cycle and etiopathogenesis of female reproductive system diseases. In this study, the vascular surface density was increased statistically in malign ovarian carcinoma, and it was higher in musinous ovarian carcinoma. Our results suggested that anti-angiogenic chemotherapy could be added to the treatment of ovarian carcinoma with increased angiogenesis. Keywords: angiogenesis, epithelial ovarian tumour, hemistry immunohistoc

Anahtar Kelimeler: