Özet:

Rosmaric acid, carnosol and carnosic acid are important natural antioxidants found in pepper (Rosmarinus officinalis). There are numerous studies reporting the biological activity of these compounds, especially the Rosmaric acid. Rosmaric acid in-vitro studies have been to have some biological activities such as anti-HIV-1, antibacterial, antioxidant, anti-cancerogenic and anti-allergic activities, antiviral properties. In vivo studies have also shown that Rosmaric Acid has anti-allergic, antithrombous and anti-cancerogenic properties. The industry is increasingly interested in natural food protectors, antimicrobial and antioxidants due to its many beneficial effects. In this study, the composition of rosmaric acid, a biologically powerful antioxidant, was extracted from the leaves of the biber. Ultrasonic-supported Extract and Surface Response Methodology has been used to optimize the conditions of the extract of antioxidants from pepper leaves. The optimum conditions for the highest levels of Rosmaric Acid (6.77) were determined as 34.37% ethanol, 37.15 minutes of extraction time and 73.38 °C of extraction temperature. In the foreseeable optimum conditions, experimental values were very close to the foreseeable values.

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