Abstract:

Purpose: We aimed at exploring the relationship between growth hormone (BH) and insulin-like growth factor - level 1 (IGF-1) and the duration of the disease and the epicardic fat thickness of patients active and in remission and the carotenous intima-media thickness. Methods: This study included 40 acromegaly patients (23 women, 17 men) and 40 control groups (23 women, 17 men). The patient’s weight, size, body mass index, back circle, systolic and diastolic blood pressure, lipid panel, insulin, glucose, urine, creatine, BH, IGF-1 levels were measured and the full blood count was done. Ecocardiographically, the epicardial fat thickness and doppler ultrasound were considered to the carotis intima-media thickness. The patient’s average age is 39.5 ± 10.1 and the control group’s average age is 39.3 ± 10. 1 year ago. The level of BH and IGF-1 in all patients was higher than the control group (p<0.001). The epicardial fat thickness in patients was significantly higher than the control group (p<0.001). The carotic intima-media thickness of patients was thicker than the control group (p<0.001). Patients had a positive correlation between the epicardial fat thickness and the carotenous intima-media thickness (R2 linear: 0.495). Conclusion: The presence of higher epicardic fat and carotenous intima-media thickness in patients with acromegaly control is an indicator of the early development of acromegaly aterosclerosis.

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