Özet:

Obesity is a chronic disorder with increasing prevalence worldwide and occurs when energy intake is greater than energy expenditure.Oxidative stress is one of the factors that cause obesity and arises from an imbalance between the reactive oxygen species and cell’s antioxidant defense system. Increasing ROS in obesity has an effect on the hypothalamic neurons which are involved in hunger and satiety control and consequently body weight control. On the other hand, weight loss due to calorie restriction or exercise reduces oxidative stress. Although the enzyme systems responsible for ROS formation and antioxidant systems are located in different parts of the cell, mitochondria is the most important source for ROS formation. In electron transfer system, reactive oxygen species forming as a result of oxidative phosphorylation reactions are involved in various physiological processes such as cell proliferation and differentiation. In the present review, the causes of increased oxidative stress in obesity are updated based on the literature.

Anahtar Kelimeler: