Özet:

Aim and Object: Micropenis is a problem that family of the patients are too sensitive especially in our society and etiology can not be detected in most of the cases. Cytogenetic studies often might be delayed in the etiology of micropenis. The aim of the study was to investigate chromosome abnormalities, after frequent reasons of micropenis were eliminated. Patients and Method: This study involved 52 prepubertal cases diagnosed as having micropenis in outpatient clinic of Pediatric Endocrinology Department between 2008 and 2009. Stretched penile length was measured by the same endocrinologist and if the lenght of the penis <10th percentile, it was accepted as micropenis. LHRH stimulated serum LH, FSH, and serum testosterone levels were studied by immuno-chemiluminometric assay (ICMA) method for all patients with micropenis. Additionally, the anterior pituitary hormones; ACTH, TSH, PRL; were also checked. Standard cytogenetic analysis was performed for all patients with normal hormonal test results.Results: Patients’ age was between 7–10.5 years and all of them were in prepubertal period. The mean peak levels of LH-RH stimulation test were 4.4±1.2 mlU/L for LH and 7.1±2.2 mlU/L for FSH. Serum testosterone level was <20 ng/dl. Serum ACTH, cortisol, PRL, TSH and fT4 levels were all normal range. Growth hormone stimulation test was not performed since none of the cases had pathological short stature. After investigation of cytogenetic analysis for 52 cases, karyotype abnormality (47, XXY; Klinefelter Syndrome) were determined in 2 cases. Conclusion: It is concluded that cytogenetic study is important to detect chromosomal abnormalities in the cases of micropenis after the common causes of micropenis are investigated. Cytogenetic study can discover cytogenetic abnormalities in the early phase of the etiological investigation. More studies are needed in this subject to become a clear conclusion

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