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Tarımsal alanlarda sorunlara yol açan allelopatik bitkilerle mücadele için kullanılan herbisitler iyi tarım ürünleri elde edebilmesi için oldukça önemlidir. Herbisit etki yorumu yapılabilmesi için, fitotoksik etkileri incelenmek üzere bir dizi özgün bileşik sentezlenmiştir. Bunun için öncelikle 2-asetilbenzimidazol pek çok basamakta elde edilmiştir. Sonrasında ikinci konumundan bir 2-aminotiyazol halkası kapatılmıştır. Bu bileşiğin amino grubu tiyoüreye çevrilmiştir. Tüm bu adımlardan sonra hedeflenen bileşiklere ulaşmak için gerekli başlangıç maddeleri elde edilmiştir. Sonrasında hazırlanan arilasetil bromür bileşikleri yardımıyla yeni bir tiyazol halkası oluşturularak hedeflenen bileşikler sentezlenmiştir. Hedef bileşikler olan 2-(4-(1-Sübstitüebenzimidazol-2-il)tiyazol-2-ilamino)-4-ariltiyazol türevleri tamamen özgün olup, yapıları, elementel analiz, IR, NMR ve MS spektral verileri yardımıyla aydınlatılmıştır. Sentezlenen bileşiklerin, biyolojik aktiviteleri Lepidium sativum L. (tere) tohumları ile test edilmiştir. Bu biyolojik aktiviteler sonucunda bileşiklerin fitotoksik etkileri bulunmuştur.
Herbicides used to fight allelopathic plants that lead to problems in agricultural areas are very important for the ability to obtain good agricultural products. For herbicide effects to be interpreted, a series of original compounds are synthesized to study the phytotoxic effects. For this first, 2-acetylbenzimidazole has been obtained in many stages. Then a 2-aminotiazole ring from the second position was closed. The amino group of this compound is converted into tiyour. After all these steps, the necessary starting materials have been obtained to reach the targeted components. Subsequently prepared arilasethyl bromure compounds were synthesized with the help of the targeted compounds to create a new tiyazol ring. The target compounds of 2-(4-(1-Substitoebenzimidazole-2-il)tiazole-2-ilamino)-4-ariltiazole derivatives are completely original, and their structures, elementary analysis, IR, NMR and MS spectral data are illuminated. The biological activity of synthetic compounds has been tested with the seeds of Lepidium sativum L. (ter). These biological activities resulted in phytotoxic effects of compounds.
Herbicides used to fight with allopathic plants causing harmful effect in agricultural lands are very important to obtain good agricultural products. To interpret of herbicidal effect a series of original compounds synthesized to investigate phytotoxic effects. For this, firstly, 2-acetylbenzimidazole has been obtained with many steps. After, it has been condensed 2-aminothiazole ring from second position of benzimidazole. After that, the amino group has been transformed to thiourea. After all of these steps, the all needed starting materials have been synthesized to attain the desired target compounds. Finally, the prepared arylacetyl bromide compounds and the starting compounds have been reacted with each other and formed new thiazole rings thus, target compounds have been synthesized. The synthesized 2-(4-(1-Substitutedbenzimidazole-2-yl)thiazole-2-ylamino)-4-arylthiazole derivatives as target compounds are novel compounds and their structures has been elucidated by using elemental analysis; IR, NMR and MS spectral data. The synthesized compounds have been tested on seeds of Lepidium sativum L. (cress) to study of their biological activities. Consequently, it was found that these compounds have phytotoxic effects based on their biological activities.
Alan : Fen Bilimleri ve Matematik; Mühendislik
Dergi Türü : Uluslararası
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