Özet:

Purpose: Frontal abdominal wall sputum (ventral hernia) is one of the common problems after abdominal surgery. This type of sputum is mostly seen after middle-line and transversal cuts, although they can be seen after any type of abdominal surgery. Although the frequency is 20%, according to the latest data, the incisional fist frequency is 2-11%. Only in the United States, 190,000 insisial hernial operations are carried out annually. The incisional sputum that occurs after the abdomen's surgery causes serious loss of workforce, morbidity and poor quality of life. It is a major surgical problem due to its high incidence and morbidity. Inciential sputum is caused by insufficient healing in the shutdown of the stomach. Obesity, tight closure of the wound edges, infection in the wound site, hematom, seroma, abdominal closure technique, steroid use, malnutrition (hipoproteinemia...), smoking, chronic obstructive lungs disease (KOAH), diabetes. In this study, the aim is to experimentally demonstrate the pathological and biochemical effects of different abdominal closing techniques in rats on cellular level wound healing. The findings: In this study, the average pain of 200-250 grams was used by Wistar Albino sex female rats. The trials were divided into five groups of eight horses in each group. Examples were taken in the form of 'U' for the patological (inflammation, angiogenesis and collogene activity) and biochemical [MDA (malondialdehitis), NO (nitric oxide), kaspas 3 activity, MMP 2-9 (metalloproteinase 2 and 9), TNF alpha (tumor necrosis factor alpha), IL6 (interlökin 6)] study, and after all these processes the rats were sacrificed. The result: According to this study, if the western phase is closed optimally (not to be closed so tightly that it does not disturb vascularity and the end-out should be closed), there is no statistically meaningful difference between the single or continuous abdominal closing technique in terms of the development of the insured fist.

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