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Amaç: Rozase yüzü etkileyen kronik, tekrarlayıcı, enflamatuvar bir deri hastalığıdır. Kronik enflamasyonun, kanser ve kardiyovasküler hastalıklar başta olmak üzere birçok hastalığın gelişimindeki rolü bilinmektedir. Bu çalışmada rozase hastalarında kardiyovasküler hastalık risk faktörlerinin araştırılması amaçlanmıştır. Gereç ve Yöntemler: Çalışmaya 97 rozase hastası ve 93 sağlıklı gönüllü dahil edildi. Rozase ve kontrol grubundaki hastaların demografik özellikleri, özgeçmiş ve eşlik eden kardiyovasküler hastalık risk faktörlerinin varlığı öğrenildi. Ayrıca laboratuvar sonuçları incelenerek açlık kan şekeri, trigliserid, total kolesterol, yüksek dansiteli lipoprotein, düşük dansiteli lipoprotein ve C-reaktif protein düzeyleri kaydedildi. Bulgular: Hasta grubunda vücut kitle indeksi, açlık kan şekeri, total kolesterol, düşük dansiteli lipoprotein ve C-reaktif protein düzeyleri kontrol grubuna göre yüksek bulundu. Ayrıca hasta grubunda obezite, prediyabet, ailede erken yaşta kardiyovasküler hastalık öyküsü ve yüksek C-reaktif protein düzeyi bulunan kişi sayısı kontrol grubuna göre yüksek bulundu. Hasta ve kontrol grupları arasında 65 yaş üstü, hipertansiyon, diyabetes mellitus, dislipidemi ve sigara gibi kardiyovasküler hastalık risk faktörleri ve alkol kullanan kişi sayısı açısından fark saptanmadı. Sonuç: Bu çalışmada rozase hastalarında ailede erken yaşta kardiyovasküler hastalık öyküsü, obezite, prediyabet ve yüksek C-reaktif protein düzeyi gibi önemli kardiyovasküler hastalık risk faktörleri kontrol grubuna göre yüksek bulundu. Kronik enflamasyonun ve doğal bağışıklık yanıtındaki bozuklukların, rozase hastalarında kardiyovasküler hastalık riskini artırdığı düşünüldü.
Purpose: Rosacea is a chronic, repetitive, inflammatory skin disease that affects the face. The role of chronic inflammation in the development of many diseases, including cancer and cardiovascular diseases, is known. This study aims to investigate the risk factors for cardiovascular disease in rosaceous patients. Tools and Methods: The study included 97 rosacea patients and 93 healthy volunteers. The demographic characteristics of patients in the Rosase and control group, resume and the presence of accompanying cardiovascular disease risk factors were studied. The study of laboratory results also recorded hunger blood sugar, triglycerides, total cholesterol, high dancite lipoprotein, low dancite lipoprotein and C-reactive protein levels. Results: The patient group found high body mass index, hunger blood sugar, total cholesterol, low dancite lipoprotein and C-reactive protein levels according to the control group. The number of people with obesity, prediabetes, early family history of cardiovascular disease and high levels of C-reactive protein was also high compared to the control group. There is no difference between patients and control groups over the age of 65, high blood pressure, diabetes mellitus, dyslipidemia and smoking, as well as the risk factors and the number of people who drink alcohol. Result: In this study, patients with rosacea found high risk factors such as early age history of cardiovascular disease in the family, obesity, prediabetes and high levels of C-reactive protein, compared to the control group. It was believed that chronic inflammation and disorders in natural immune response increased the risk of cardiovascular disease in rosaceous patients.
Objective: Rosacea is a chronic, recurrent, inflammatory skin disease affecting the face. The role of chronic inflammation is known in the development of many diseases, especially cancer and cardiovascular diseases. This study aimed to investigate the risk of cardiovascular disease in rosacea patients. Material and Methods: This study included 97 rosacea patients and 93 healthy volunteers. Patients in the rosacea and control groups were examined for demographics, medical history and the presence of associated cardiovascular disease risk factors. Laboratory investigations including fasting blood glucose, triglyceride, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and C-reactive protein levels were recorded in the rosacea and control groups. Results: Body mass index, total cholesterol, low-density lipoprotein cholesterol, fasting blood glucose and C-reactive protein levels were higher in the patient group. Obesity, prediabetes, family history of premature cardivascular disease and high C-reactive protein levels in the patient group was significantly higher than the control group. There was no significant difference between patient and control groups in terms of age over 65 years old, hypertension, diabetes mellitus, dyslipidemia, smoking and alcohol consumption. Conclusion: In this study, significant cardiovascular disease risk factors such as a family history of premature cardiovascular disease, obesity, prediabetes and high C-reactive protein levels were found to be higher in rosacea patients. Although the underlying mechanism is not clear, it is thought that chronic inflammation and disregulation of innate immune system increase risk of cardiovascular disease in rosacea patients.
Alan : Sağlık Bilimleri
Dergi Türü : Uluslararası
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