Özet:

This study aims to determine the effects of streptozotocin-induced diabetic on mineral density and bone structure in the femur of rat and whether of carnosine has a beneficial effect on these changes. In this study, 32 male Wistar rats weighing 350-400 gr were used. Four different groups were formed including control, carnosine, diabetes and diabetes+ carnosine. After three weeks from experiment, right femurs of the rats were removed. The bone tissues cut parallel to long axis were observed by scanning electron microscope in back scattered electron (BSE) mode. Additionally, mineral analysis was performed with energy-dispersive system (EDS). In observations with scanning electron microscopy, no significant difference of bone structure and trabecular thickness was found between control, diabetic, carnosine with diabetic-carnosine groups. When we compared all the groups in terms of bone mineral density (BMD) neither the diaphysis nor the epiphysis of femur was statistically significant. As a result, streptozotocin-induced diabetes caused decrease in BMD, but this change, was not affected by carnosine.

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