Özet:

Introduction: Plants have always been a very good source of drugs. Liver disorders are nearly one of the lethal ailments in the globe now a day. Hence, in the present study, we intend to evaluate the hepatoprotective study of Grewia asiatica. Materials and Methods: G. asiatica was collected from hills of Tirupati, dried, and powdered. Healthy male Wistar albino rats with paracetamol and CCl4-induced liver damage were studied on day 1 and 7 for the serum glutamate oxaloacetate transaminase (SGOT), serum alanine transaminase (SGPT), ALKP, and total protein levels after the extract was given at different concentrations. The results were compared histologically. Results: The hepatoprotective effect of the plant extract and combination also proved by measuring the liver related parameters such as SGOT, SGPT, ALKP, and total protein which were elevated in disease but significantly reduce in standard and plant extract treated groups. Conclusion: G. asiatica plant extracts were safe for treating the hepatic diseases and did not show any toxicities or drug-related interactions but future pharmacokinetic studies required to validate the given result.

Anahtar Kelimeler: