Abstract:

In helicobacter pylori eradication, the first choice is triple therapy with macrolide group antibiotics. Due to its antibiotic resistance, the effective and easily accessible alternative to this regime is the hybrid protocol. In the hybrid treatment plan, changes were made using tetracycline instead of macrolide antibiotics. It is aimed to present the eradication rates obtained after treatment according to this regulation. METHODS: 1570 esophagogastroduodenoscopy procedures performed at Babeski State Hospital and Zeynep Kamil Gynecology and Pediatric Education and Research Hospital were evaluated. Pathology reports of biopsy samples were analyzed retrospectively in cross-section. According to the pathology reports, a modified hybrid treatment protocol was applied to the group of patients who had a helicobacter pylori infection and were indicated for eradication therapy. Patients who accepted the procedure underwent control endoscopic biopsy four to six weeks after treatment. Helicobacter pylori antigen was examined in the stool in the patient group who did not want to repeat the procedure. Results: The presence of helicobacter pylori was shown in 828 (52.7%) of the patients. 1444 (92.1%) gastritis, 126 (7.9%) gastropathy were diagnosed. No infection was detected in any patient with gastropathy, and it was shown in 828 (57.2%) of those diagnosed with gastritis. Gastric intestinal metaplasia and gastric mucosal atrophy were observed simultaneously in 124 (14.8%) of those with infection, and were not detected in 151 patients (18.2%) even though they had an infection. Eradication therapy was applied in all patients with Helicobacter pylori positive, gastric intestinal metaplasia and gastric mucosal atrophy findings, even if the patients were asymptomatic. 218 of 658 patients undergoing modified hybrid treatment protocol underwent control endoscopic biopsy between the fourth and sixth weeks after treatment, and no infection was detected in 203 (93.2%) of them. 455 patients did not have control endoscopy. Helicobacter pylori antigen could be examined in 283 individuals from this group and 262 (92,5%) test negative. Discussions and conclusions: Upper gastrointestinal system endoscopy is not just a diagnostic tool. It also allows for many therapeutic procedures to be performed. Making the right treatment depends on the correct diagnosis. Taking appropriate biopsies are therefore important. The proper theoretical and practical training of the endoscopist is important for the effectiveness of the procedure.

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