Abstract:

Background: Diabetes mellitus (DM) is an urgent global health issue with increased annual prevalence. The uncontrolled hyperglycemia may induce an oxidative stress state which could lead to the development of diabetic related complications. Several studies showed that mahogany seed contains 1,4-bis-3,4,5-trimethoxy-phenyl-tetrahydro-furo(3,4-c) furan which has glucose-lowering properties. However, its efficacy toward oxidative stress condition is yet to be investigated. Objectives: This study aimed to examine the activity of 1,4-bis-3,4,5-trimethoxy-phenyl-tetrahydro-furo(3,4-c) furan in reducing the malondialdehyde (MDA) level as oxidative stress biomarker and blood glucose levels in diabetic rats. Method: 36 male Wistar rats were used and divided randomly into six groups: Normal control, DM, DM+glibenclamide, DM+isolate10, DM+isolate20, and DM+Isolate40. The isolate and glibenclamide were given for 21 consecutive days. Streptozotocin and nicotinamide were used to induce the diabetic model. Levels of glucose and MDA were measured in successive phases: Before induced by streptozotocin and nicotinamide; before treatment; and after 7, 14, and 21 days of treatment. Results: Within 21 days of treatment, mean glucose and MDA levels in each therapy group: (DM+glibenclamide, DM+isolate10, DM+isolate20, and DM+Isolate40) showed significant decreases over time. Mean of glucose and MDA levels in the therapy groups were significantly lower than in DM (diabetic control) group. Mean of glucose level in DM+Isolate40 group was significantly different from the normal control group but the MDA level showed no significant difference. The results between the DM+Isolate40 group and DM+glibenclamide group showed no significant difference. Conclusion: The 1,4-bis-(3,4,5-trimethoxy-phenyl)-tetrahydro-furo(3,4-c) furan had significant glucose lowering and anti-oxidant effect in diabetic rats.

Keywords: