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Bu derlemedeki amacımız, çocuklarda löseminin erken teşhis edilmesi, klinik özellikleri, komplikasyonları ve ağız içi tedavi yaklaşımları hakkında bilgi vermektir.PUBMED, RESEARCH GATE ve GOOGLE SCHOLAR arama motorlarında ‘leukemia in children’; ‘oral manifestations for leukemia’ ; ‘leukemia oral symptoms’ kelimeleri aratıldı. Literatürlerin başlık ve özetleri değerlendirildi, uygun literatürler seçilerek analiz edildi.Lösemi hematopoetik hücrelerin normalden fazla çoğalmasıyla seyreden malign bir hastalıktır. Etiyolojisi kesin değildir. İlerleme şekline göre akut ve kronik olabilir. Bunun dışında hücrelerin tipine göre ana olarak lenfositik ve myolositik olarak da sınıflandırılır. Tedavisi remisyon indüksiyonu, konsolidasyon ve idame tedavisi olmak üzere üç aşamada yapılır. Yüksek risk grubu lösemi hastalarında kemik iliği nakli yapılması tercih edilebilir. Löseminin tipleri ve tercih edilen tedavi şekline göre ağız içi bulgular farklılık arz edebilir. Semptomlar daha çok pansitopeni (anemi, nötropeni ve trombositopeni) nedeniyle oluşur. Mukozal solgunluk, dişeti kanaması, ekimoz, ülserasyon, trismus, gingival hiperplazi ve mukozal enfeksiyonlar en fazla gözlenen bulgulardır. Tedavi sırasında ve sonrasında ise yapılan işlemlere bağlı olarak mukozitis, kserostomi, deskuamasyon, kandidiazis görülmektedir.Lösemi çocukluk döneminde en fazla görülen malign hastalıktır. Vücudun diğer bölgelerinde olduğu gibi ağız içinde de bulgu verir ve henüz tanı konmamış kişilerde hastalık açısından yönlendirici olabilir. Hastalığın tanısında diş hekimlerine büyük sorumluluk düşmektedir.
Aim of present review is to provide information about the early diagnosis of leukemia, clinical features, complications, and oral treatment approaches in children.The words 'leukemia in children'; 'oral manifestations for leukemia'; 'leukemia oral symptoms' were searched in PUBMED, RESEARCH GATE and GOOGLE SCHOLAR search engines. The titles and summaries of the literatures were evaluated, and appropriate literature was selected and analyzed.Leukemia is a malignant disease with hematopoietic cells multiplying more than normal. Its etiology is uncertain. The disease can be acute and chronic, depending on how it progresses. It is classified as lymphocytic and myolocytic depends on the histological type of cells. The treatment is carried out in three stages: remission induction, consolidation and maintenance therapy. Bone marrow transplantation can be preferred in patients with high risk of leukemia. Intraoral symptoms and treatment may differ depending on the types of leukemia. Symptoms are mostly caused by pancytopenia (anemia, neutropenia and thrombocytopenia). Mucosal paleness, gingival bleeding, ecchymosis, ulceration, trismus, gingival hyperplasia and mucosal infections are the most common symptoms. Because of the procedures performed, during and after treatment mucositis, xerostomy, desquamation can be observed. Leukemia is the most common malignant disease in childhood. Like the other parts of the body, it gives symptoms in the mouth and can be a guide for the diagnosis of disease. Dentists have a great responsibility in the diagnosis of the disease.
Aim of present review is to provide information about the early diagnosis of leukemia, clinical features, complications, and oral treatment approaches in children.The words ‘leukemia in children’; ‘oral manifestations for leukemia’; ‘leukemia oral symptoms’ were searched in PUBMED, RESEARCH GATE and GOOGLE SCHOLAR search engines. The titles and summaries of the literatures were evaluated, and appropriate literature was selected and analyzed.Leukemia is a malignant disease with hematopoietic cells multiplying more than normal. Its etiology is uncertain. The disease can be acute and chronic, depending on how it progresses. It is classified as lymphocytic and myolocytic depend on the histological type of cells. The treatment is carried out in three stages: remission induction, consolidation and maintenance therapy. Bone marrow transplantation can be preferred in patients with high risk leukemia. Intraoral symptoms and treatment may differ depending on the types of leukemia. Symptoms are mostly caused by pancytopenia (anemia, neutropenia and thrombocytopenia). Mucosal paleness, gingival bleeding, ecchymosis, ulceration, trismus, gingival hyperplasia and mucosal infections are the most common symptoms. Because of the procedures performed, during and after treatment mucositis, xerostomy, desquamation can be observed. Leukemia is the most common malignant disease in childhood. Like the other parts of the body, it gives symptoms in the mouth and can be a guide for diagnosis of disease. Dentists have a great responsibility in the diagnosis of the disease.
Field : Sağlık Bilimleri
Journal Type : Uluslararası
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