Abstract:

Background: Infection and inflammation will stimulate the acute phase response (APR) activation which will cause the changes in lipid metabolism. In rodents, the infection will induce an increase in cholesterol, including LDL, whereas in the primates and humans, LDL levels will decrease or normal. As lipopolysaccharides (LPS) and cytokines will lower the total cholesterol level in primates, while in mice will increase due to the stimulation of infection enhance the cholesterol synthesis de novo, reducing the lipoprotein clearance, and lowering the cholesterol conversion into bile acid. Aim: This study aims to determine the influence of the bacterial sepsis severity to the value of Low-Density Lipoprotein (LDL) Methods: It was a case-control observational study which conducted from January-March 2017 to the 30 sepsis patients and 30 non-sepsis patients at Haji Adam Malik General Hospital, Medan. Data were collected by measuring LDL and PCT levels in both sepsis and non-sepsis patients on days 0, 3, and 5 of study then was analyzed by using Mann-Whitney test to assess the relationship between them.  Results :  The result showed that LDL value in sepsis group on pretreatment was 77,70 ± 33,42 mg / dl and increased on day 3 and 5 treatment to 83,50 ± 38,68 mg / dl. In the non-sepsis group, the mean value of LDL at baseline was 102.23 ± 45.90 mg/dl and increased on day 3 and 5 of treatment to 114 ± 38.58 mg/dl. Statistically, there were significant differences in LDL levels between sepsis and non-sepsis groups on the first day of treatment, day 3 and day 5 of care (p <0.05). Spearman correlation test results obtained a significant negative correlation between LDL levels with sepsis degree with correlation strength is moderate (r = -0.318). Conclusion: There was a significant relationship between the severity of sepsis and the LDL value in patients with sepsis.

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