Özet:

Aim: Neuroendocrine cell groups seen in the appendix are defined as proliferative phenomenon similar to early neuroendocrine cell proliferation seen in other organs of the gastrointestinal tract. Neuroendocrine tumors (NET) account for 0.3-0.6% in in appendectomy materials. Rarely, appendicular collusion tumors have also been reported. Here, we presented appendiceal neuroendocrine neoplasms including rare cases. Method: Appendectomy materials were reviewed between 2011-2020 and cases with neuroendocrine cell hyperplasia and NET were included in the study. The demographics of the cases, the size of the tumors, their localization, their dissemination, and their lymphovascular, perineural and mesoappendix invasions were evaluated, along with their clinical follow-ups. Results: There were 4,433 appendectomy cases; 10 had neuroendocrine cell hyperplasia and 50 (1.1%) had NET. Fourty-for cases were grade 1 and six of them were grade 2. The mean diameter of tumors was 0.7 cm (0.1-2.5 cm). In 36 cases, the tumor was localized in tip, in nine in body, and in five in tip + body. Tumor invaded submucosa in 14, muscle tissue in 17, subserosa/mesoapendix in 19. Two cases were in the collusion tumor group and low grade appendiceal mucinous neoplasia was detected as the secondary tumor. Two of the cases, whose clinical follow-ups were still continuing, died. Conclusion: In our study, the rate of NETs was slightly higher than the literature. Careful microscopic examination with accurate sampling is important in the detection of these tumors most of which are microscopic in size. Also, as in our study, two different tumors can take place simultaneously in the appendix.

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