Abstract:

Purpose: Metabolic syndrome (MetS) is an endocrinopathy. Neuromedin U (NMU) is a candidate decretin hormone known to be secreted from the upper GIS region, and studies have shown that NMU suppresses glucose-stimulated insulin secretion. In our study, we aimed to determine the basal NMU levels and NMU response to the oral glucose tolerance test (OGTT) in the MetS model based on high fructose diet. Materials and methods: A total of 26 Wistar albino male rats, including the control group (C) (n=13) and the metabolic syndrome (MetS) (n=13) group, were used in the study. The MetS model was created by mixing 20% fructose into the water of 3-month-old rats for 19 weeks. Group C was given only normal water. At the end of the experiment, in both groups; body weight, TCHOL, TG, HDL abdominal obesity, plasma insulin level, OGTT, HOMA-IR score and plasma NMU level were evaluated. Results: The data obtained showed that in MetS rats fed high fructose diet, the NMU levels at the 60th and 120th minutes of basal and OGTT were significantly higher than in the C group (p<0.05). No significant difference was found between the two groups in terms of body weight, TCHOL, TG, HDL, retroperitoneal fat amount, insulin level, OGTT, HOMA-IR score (p>0.05). Conclusion: An effective MetS model could not be established in rats fed a high fructose diet. The increase in NMU response to OGTT at both basal and stimulated levels in the MetS group was considered as a compensatory response to prevent hyperinsulinemia. Key words: High fructose diet, neuromedin

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