Abstract:

Background and aims: Portal hypertension leads to considerable hemodynamic changes in the splanchnic circulation. Although nitric oxide may enhance functional mucosal continuity as a potent mediator, it may produce a paradoxical influence. The aim of the study was to assess the histopathologic changes in the digestive tract and evaluate the potential influence of portal hypertension on bacterial translocation together with the role of nitric oxide. Materials and methods: Twenty male Wistar rats used for the study were randomized into two groups. Portal vein constriction was performed in the first group while the second underwent Sham operation. Twelve weeks later portal venous pressures were registered. Intestinal samples were taken for nitric oxide levels and histological examinations. Liver, spleen, and mesenteric lymph node complex were harvested for cultures. Results: Portal venous pressures (22.7±5.7 cmH2O) were significantly higher in the constriction group compared with the sham operation group (10.4±1.5 cmH2O) (p0.05). Conclusions: Increased portal venous pressure was obtained with constriction. Intestinal barrier was not significantly altered in our groups.

Keywords: