Abstract:

Purpose: Allogenic bone marrow transplantation with hematopoetic root cell transfer is a method used in the treatment of various genetic, immune disorders, hematological and solid organ malignities. Graft versus host disease is one of the main and fatal complications of alloogenic bone marrow transplantation. It is a systemic disease that affects the five main areas of the skin, the gastrointestinal tract, the liver, the lungs and the hematopoetic system. The diagnosis of Cutanose Graft Versus Host disease is placed by the correlation of the patient's clinical findings with the histopathological findings. The aim of our study is to determine the incidence rate of cataractic graft versus host disease in patients with allogenic bone marrow transplantation in our center, to discuss the histopathological characteristics of the disease and the distinctive diagnosis in literature accompanied. Instruments and methods: In our institution between January 2015 and January 2019 allogenic bone marrow transplantation was carried out and the skin biopsy preparations of the Patients, who have been diagnosed with graft versus host disease in our pathology department, were re-evaluated and the epidermal and dermatological histomorphological findings were classified. Clinical and demographic data of patients. The rate of occurrence of Graft versus Host disease has been determined. Results: From January 2015 to January 2019 at our center, a total of 273 patients, including pediatric 173, adult 100, were allogenic, and 181 patients were autologist bone marrow transplants. In 23 patients with allogenic bone marrow transplantation, cutanosis was observed, and in 21 gastrointestinal graft versus host disease. The incidence rate of cutanous and gastrointestinal Graft Versus Host disease was 16.1%, while the incidence rate of cutanous Graft Versus Host disease was only 8.42. The most frequent drug reaction was among the clinical pre-diagnoses of Cutanose Graft versus Host disease (74%). The most common epidermal histomorphological discovery in preparations was keratinosite necrosis (87%). This was followed by vacuole degeneration (%63) in basal keratinosites, respectively, and Achanthosis and spongiosis (%61) respectively. The most common outcome in the dermatitis was Pigment incontinence (59%). 56% of the patients diagnosed with Graft Versus Host disease were transplanted from donors who were not relatives and 44% from donors who were relatives. Conclusion: Cutanosa Graft Versus Host Disease is a common complication of allogenic hematopoietic root cell transplantation. It is associated with high mortality rates and is a disease that has a clear negative impact on the patient’s quality of life. Dermatologically, the early recognition of the disease; the histopathological assessment and verification, along with distinctive diagnoses, plays a key role in the prevention of patient morbidity and mortality. (SETB-2019-09-118)

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