Özet:

There is growing evidence for an association between adipokines and allergic disorders but little is known about the underlying mechanisms. We hypothesized that high plasma leptin and adiponectin concentrations might be related to asthma and the other allergic diseases. We studied 71 children with allergic diseases (asthma, allergic rhinitis, atopic dermatitis) and 54 healthy children. Body mass indexes, pulmonary function tests and skin prick test were performed.  Total eosinophil count, total serum immunoglobulin E (IgE), serum specific IgE (phadiotop) leptin and adiponectin were measured in all subjects. There was a strong positive correlation for plasma leptin concentrations with body mass index BMI, Adiponectin, however, was negatively correlated with BMI. Children with atopic dermatitis had higher levels of leptin compared to the other allergic diseases and control groups, but adiponectin did not show any difference between these three groups. Serum leptin levels are strongly correlated with measurements of BMI. These results suggest that leptin may contribute to increased atopic dermatitis risk in children. but no correlation was found with plasma adiponectin concentrations

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