Abstract:

This study takes place in two continued experiments! In the id. In the first experiment, the normal wing pancreatic histology of the most mature chickens was studied in a histological and histochemical way. The exocrine part was in asiner structure with the pyramidal eprtel cells. The apical parts of the asiner cells were filled with zymogenic granules. Intermediary channels with single-storey flat epithelial layers of the walls between the asins were often found. In the second part of the experiment, when 5% alloxan (alloxan tetrahydrate-Merck) was given in intravenous way at a dose of 250 mg/kg, endocrine cells were observed to be destroyed. In the t. hour following the application of Alloksan, the blood sugar level suddenly rose to 315.7 mg/100ml, and the degree increased to 396.8 rng/100ml, the highest level in the 28th hour. In unapplicated normal animals, the level was 180-260 mg/100 ml. As shown in the cuts painted by Gomori's Chrome alum haematoxylin-phloxine technique, 1 hour after alloksan application, zymogenic granules disappeared. In the beta cells in the endocrine islands, picnic and caryolysis were detected in the nucleus, along with typical degranulation that lasted until 48 hours after alloxan was applied. Dejenere islands around the asiner epttelde. Observed severe cellular changes that began in 5 hours after the application. The changes continued with the appearance of basophilic granules in the asiner cell cytoplasm and the cells gained a more round shape. The blood sugar level. It fell to normal levels after 48 hours (222 mg/100 ml). Asiner epithelial cells were observed among the endocrine cells to degenerate in the islands 1 week after application. This is. It was also seen in subsequent periods of time and was interpreted as a regeneration formed by the transformation into the beta cells of the asiner epithelium.

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