Abstract:

A series of some novel isoxazole derivatives were synthesized via chalcones under microwave irradiation. Isoxazoles are the unsaturated five-membered heterocyclic aromatic compounds containing three carbon atoms, one oxygen atom, and one nitrogen atom in a ring system. Isoxazole derivatives play a vital role due to their diverse biological activities including antimicrobial, antifungal, anti-viral, anti-tubercular, anti-diabetic, anticancer, anthelmintic, antioxidant, anti-epileptic, antipsychotic, antimalarial, analgesic and anti-inflammatory, etc. Similarly, Chalcones demonstrate diverse pharmacological properties including antioxidant, anti-inflammatory, antiviral, antidiabetic, antispasmodic, and antitumor. These activities are exhibited due to the presence of α, β-unsaturated carbonyl system in chalcone. Hence, chalcones are utilized as a synthon for the synthesis of isoxazole derivatives with diverse structural features. For rapid heating, enhanced rate of reactions, improved product yield, and cleaner reactions, and homogeneity, the microwave-assisted synthetic technique is applied for the synthesis of isoxazole derivatives. The synthesized compounds were characterized by spectral data including FT-IR, 1H-NMR, LC-MS. The titled compounds were evaluated for their anti-microbial activity. Tested compounds exhibited promising anti-microbial activity as compared to standard drugs.

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