Özet:

Purpose: This study aims to determine the rates of antibiotic sensitivity and lead to ampyric antibiotic therapy of patients followed by our hospital from foot and bed, which are isolated from the sub- respiratory patterns and are important infectious factors of respiratory infections, such as Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pneumoniae. Tools and Methods: The sub-death sample sent from various clinics to the Medical Microbiology Laboratory of the University of the Nine-May Medical Faculty Hospital in the years 2015-2017 has been retrospective examined. Isolates are identified by Vitek MS (Biomerieux, France) device; antibiotic sensitivities are determined by Vitek 2 Compact (Biomerieux, France) device and Mueller-Hinton Fastidious (Biomerieux, France) agarda disk diffusion method. The obtained sensitivity rates have been evaluated according to EUCAST (European Committee on Antimicrobial Susceptibility Testing) criteria Results: 2427 seeds isolated from the sub- respiratory tract samples have been examined as retrospective. 67% penicillin resistance, 58% erythromycin resistance, 9% erythromycin resistance, 9% seftriaksin resistance, 3% seftriaksin resistance, and 92% erythromycin resistance, 33% seftriaksin resistance to Moraxella catarrhalis, and 92% erythromycin resistance to Haemophilus influenzae. The result: The resistance to the antibiotics used in the routine against these three bacterial pathogens, which are isolated by the lower breath, increases every day. After the effect is determined, the conduct of antibiotic sensitivity tests is important for the guidance of the treatment.

Anahtar Kelimeler:

Özet:

Aim: In this study, it was aimed to determine antibiotic susceptibility rates of  Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pneumoniae strains isolated from lower respiratory tract samples of hospitalized patients and to guide empirical antibiotic treatment of respiratory tract infections. Material and Methods: The lower respiratory tract samples sent from various clinics to the Ondokuz Mayıs University Medical Faculty Hospital Medical Microbiology Laboratory in 2015-2017 were retrospectively examined.  Identification of isolates Vitek MS (Biomerieux, France) device; antibiotic susceptibilities were determined by the Vitek 2 Compact (Biomerieux, France) instrument and disk diffusion method in Mueller-Hinton Fastidious (Biomerieux, France) agar. The sensitivity ratios obtained were evaluated according to EUCAST (European Committee on Antimicrobial Susceptibility Testing) criteria Results: A total of  2427 strains isolated from lower respiratory tract specimens were examined retrospectively. 67% penicillin, 58% erythromycin resistance against Streptococcus pneumoniae isolates; 9% erythromycin, 9% cefotaxime, 3% ceftriaxone resistance to Moraxella catarrhalis; Haemophilus influenzae had 92% erythromycin and 33% cefotaxime resistance. Conclusion: Resistance is increasing day by day against antibiotics used in routine against these three bacterial pathogens most commonly isolated in lower respiratory tract. Antibiotic susceptibility tests should be performed after the agent has been identified in order to direct treatment.