Citation Number
1
Views
7
SüleymanDemirel Üniversitesi TIP FAKÜLTESİ DERGİSİ: 2007 Mart; 14(1) Nöroprotektif tedavide yeni bir ilaç hedefi: İkinci jenerasyon tetrasiklinler İsmail Yılmaz İzmir Eğitim ve Uygulama Hastanesi, Bozyaka\ İzmir Özet Minosiklin ve doksisiklin yüksek lipofilik özellikli ikinci jenerasyon tetrasiklinlerdir ve her iki ilaç da kan-beyin engelini kolayca geçebilir. Bu ilaçların antimikrobiyal özelliklerinden tamamen ayrı bir şekilde anti-inflamatuar özellliklerinin de bulunduğu belirlenmiştir. Yakın zaman önce yapılan çalışmalar minosiklinde daha belirgin olmak üzere ikinci jenerasyon tetrasiklinlerin global ve fokal beyin iskemisinde, Huntington hastalığında, amyotrofik lateral sklerozda, Parkinson hastalığında, multiple sklerozda, travmatik beyin hasarı ve medulla spinalis zedelenmesinde nöroprotektif etkileri olduğunu ortaya koymuştur. Nöroprotektif özellikte başta mikrogliyal aktivasyonun inhibisyonu olmak üzere anti-apopitotik ve anti-inflamatuar etkinliğin önemli rolü vardır. Bu bilgilerin daha fazla sayıda deneysel ve klinik çalışmalarla desteklenmesi, nöronal ölümle giden bir çok serebral hastalıkta başta minosiklin olmak üzere bu ilaçların güvenli bir şekilde kullanımına ışık tutacaktır. Anahtar kelimeler: Minosiklin, doksisiklin, nöroprotektif tedavi Abstract Second generation tetracyclines:A novel drug target for the neuroprotective therapy Minocycline and doxycycline are second generation tetracyclines that have high lipophilic properties and degree of access to brain. These drugs have antiinflammatory properties independent of their antimicrobial activities. Recently, it has been shown that these drugs (especially minocycline) display neuroprotective activity in animal models of global and focal cerebral ischemia, Huntington's disease, amyotrophic lateral sclerosis, Parkinson's disease, multiple sclerosis, traumatic brain injury and spinal cord injury. Mainly microglial activation's inhibition, then, antiapoptotic activity and antiinflammatory activity play an important role on neuroprotection's features. To support these information by more clinical and experimental studies light the way for second generation tetracyclines, especially minocycline in cerebral diseases with neuronal death. Key words: Minocycline, doxycycline, neuroprotection
SuleymanDemirel University TIP FACULTY JOURNAL: March 2007; 14(1) a new drug target in neuroprotective therapy: Second generation tetracyclines Ismail Yılmaz Izmir Education and Application Hospital, Bozyaka\ Izmir Summary Minoscycline and doxycycline are second generation tetracyclines with high lipophyllic characteristics and both drugs can easily pass the blood-brain block. These medications have been identified to have anti-inflammatory properties completely distinct from their antimicrobial properties. Recent studies have shown that second-generation tetracyclines have a neuroprotective effect on global and focal brain ischemic, Huntington disease, amyotrophic lateral sclerosis, Parkinson disease, multiple sclerosis, traumatic brain damage and medulla spinalis sclerosis. In the neuroprotective properties, the important role of anti-apopitotic and anti-inflammatory activity, primarily inhibition of microglyal activation, is played. The support of this information by more experimental and clinical studies will give light to the safe use of these medications, primarily minosiclins, in many neuronal deaths. A novel drug target for the neuroprotective therapy Minocycline and doxycycline are second generation tetracyclines that have high lipophilic properties and degree of access to the brain. These drugs have anti-inflammatory properties independent of their antimicrobial activities. Recently, it has been shown that these drugs (especially minocycline) display neuroprotective activity in animal models of global and focal cerebral ischemia, Huntington's disease, amyotrophic lateral sclerosis, Parkinson's disease, multiple sclerosis, traumatic brain injury and spinal cord injury. Mainly microglial activation's inhibition, then, antiapoptotic activity and anti-inflammatory activity play an important role on neuroprotection's features. To support this information by more clinical and experimental studies light the way for second generation tetracyclines, especially minocycline in cerebral diseases with neuronal death. Key words: minocycline, doxycycline, neuroprotection
Field : Sağlık Bilimleri
Journal Type : Uluslararası
Article Detail 
Citation Owners
Similar Articles
Journal Information
Listen Paper
Print This Page
Share
Mendeley
