Özet:

Lansoprazole is proton pump inhibitor which extensively degraded in acidic pH conditions. Lansoprazole loaded nanosponges were prepared by Emulsion solvent diffusion method using ethylcellulose, PVA and pluronic F-68 and dichloromethane as a solvent. The prepared nanosponges were evaluated for percentage yield, incorporation efficiency, particle size, drug polymer compatibility, scanning electron microscopy and in-vitro drug release. SEM studies confirmed their porous structure with number of nanochannels. The FTIR spectra showed stable character of lansoprazole in mixture of polymers and revealed the absence of drug polymer interactions. DSC study revealed that drug was involved in complexation with nanosponges. The average particle size of lansoprazole nanoparticles was found to be in the range of 83.4 nm to 190.69 nm. The negative zeta potential values were attained to ensure a good stability of nanosponges. The drug release from nanosponges was found to extended upto 12 h. The optimized nanosponges were formulated in to enteric coated tablet and evaluated for weight variation, hardness, friability and dissolution studies. In-vitro release of drug from enteric coated tablet follows zero order and showed controlled release behavior for a period of 24 h. The data obtained in this study suggests that nanosponges of lansoprazole are promising for controlled drug delivery, which can reduce dosing frequency.

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