Özet:

ABSTRACT Background: Controlled ovarian hyperstimulation (KOH) is the basis of in vitro fertilization (IVF) treatments. At the same time, follicle-stimulating hormone (FSH) is the primary regulator of the growth of antral follicles. Luteinizing hormone (LH) is also effective in supporting steroidogenesis. Although LH is effective in ovarian stimulation, there is no clear consensus in the literature about adding LH supplementation to KOH. In our study, We aimed to compare to retrospectively analyzed the efficacy and safety of using recombinant luteinizing hormone (rLH) and recombinant follicle-stimulating hormone (rFSH) and rFSH alone for ovarian stimulation in women undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) in cases in our clinic. Materials and Methods: 89 infertile couples treated at Sakarya University Training and Research Hospital IVF Center between 2019-2020 included in our study. The data of patients with a normal ovarian function who treated with IVF were analyzed. For KOH, the results of patients who used rFSH (Gonal-F) alone and rFSH (Gonal-F) and r-LH (Luveris ) together were compared retrospectively. In addition, rFSH, rFSH+rLH stimulation results were evaluated as a subgroup for the patient groups over 35 years old and under 35 years old. Our study also compared the total number of oocytes, total metaphase II (MII) numbers, and pregnancy rates. Results: Of the 89 patients included in the study, 40 were in the rFSH group (Group 1), and 49 were in the rFSH + rLH (Group 2) group. No statistical difference was observed between the groups except the total gonadotropin amount and stimulation days When evaluated within all age groups. When the patients over 35 years old and under 35 years old assessed separately; There was no statistically significant difference between the two groups in terms of oocytes count, total MII oocytes, Grade I embryo count and clinical pregnancy rates. Conclusions: Although the results were more positive in the r-LH group, we could not detect a statistically significant difference between the stimulation protocols with and without r-LH in the 35-40 age range, a regular patient population with ovarian reserve. As in our study, we were adding r-LH to the controlled ovarian stimulation protocols used in IVF_ICSI applications does not seem to affect treatment success in women of all age groups. However, we believe that studies with a more significant number of patients should be conducted.

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