Abstract:

This study aims to identify the effect of the extract of Cinnamomum zeylanicum, which is used as spices worldwide and has a widespread consumption among the public on the formation of in-vivo micronucleus in the femur bone marrow cells of diabetic rats. In the study, 40 male Spraguey Dawley rat were used. The trial groups were identified as control, tarshine, diabetes and diabetes + tarshine. Diabetes and diabetes+diabetes were created by injection of STZ (Streptozotosin) in the group (i.p). Later, the clay and diabetes+ clay groups were given the clay extract by oral garment, which will be 200mg/kg for 14 days. At the end of the study, a micronucleus test was applied by taking the femur bones after the cervical dislocation was applied to rats. According to statistical analyses, the number of micronucleus polycromatic erythrosite (MNPCE), polycromatic erythrosite (PCE) and normocromic erythrosite (NCE) increased according to the groups given by control and chili extract, and the number of chili extract with diabetes increased according to the group given by diabetes (P<0.001). As well as the PCE/NCE ratio was assessed, the lowest rate was found in the diabetes group, and this rate was also increased due to the application of chicken extract to diabetic animals. As a result, the number of micronucleus in the rat formed with STZ and diabetes increased, while the protective effect of the wheat in the group of diabetes + wheat was noticeable and the number of micronucleus was reduced.

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