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EMG, MAPK ve inflamasyona yakından bakış: Fare embriyonik kök hücre, somatik ve kanser hücrelerinde ne farklıdır?
2018
Journal:  
Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi
Author:  
Abstract:

Objective: Life is a continuous cycle of the cells, composed of beginning, surviving and death. Cells keep dividing, differentiate and turn into somatic cells. The somatic cells at some point can give way to cancer cells and share characteristics of stem cells. The processes during these periods are important for identifying the tendency to abnormality and transformation to the cancer cells in somatic cells. To control emergence and progress of the cancer, mechanisms which take part in the survival become significant, especially EMT and inflammation. EMT occurs in both embryonic developmental stages and cancer progression and molecular basis of this process can be the therapeutic target for cure. Material and Method: For cancer representation mouse squamous lung cancer cells (SqLCCs), for somatic origin mouse skin fibroblasts (MSFs) and for embryonic stem cell mouse embryonic stem cells (mESCs) were used for comparison of three signaling pathways (EMT, MAPK and inflammation) at the gene expression level. Immunofluorescence staining protein levels of ERK 1/2, Vimentin and Twist were compared. Results: ERK1/2 protein expression similar in MSFs and SqLCCs while mESCs expression wasthe lowest. Besides, Twist and Vimentin expression statistically different in three. According to gene expression profiling of the EMT and inflammation supported by the MAPK signaling pathway are a far cry from each other at prominent genes especially Sparc, Vimentin, Mapksp1 and Il24.

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Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi

Field :   Sağlık Bilimleri

Journal Type :   Ulusal

Metrics
Article : 529
Cite : 1.379
2023 Impact : 0.024
Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi