Özet:

Introduction and Purpose: COVID-19 is seen in children with relatively lighter clinical symptoms compared to adults. In this study, we aimed at detecting hematological and immune changes observed during the diagnosis. Material and Method: 22 (6 girls, 16 men) COVID-19 patients were taken to the study. It was approved by the Ethics Board. In COVID-19 patients, subgroups of lymphocytes were studied as hemogram, protrombin time (PT), active partial tromboplastin time (aPTT), fibrinogenic, D-Dimer and immune parameters as flow sitometry. The average age of patients was 8.1 (2.3-17,5) years. Patients were divided into age groups in order to compare the achieved values with the normal values in literature. The media WBC number was 6.145 (3.137-11.000) /μL found. As the age of children grew, the number of white cells tended to decrease. The differences between the monocytes are identified. There was no difference between the groups in terms of eozinofil, platelet/lenfocyt ratio (PLR), PT, aPTT, fibrinogen, D-Dimer. In the 2-5-year-old group of our patients, Helper T cells were reduced and cytotoxic T cells increased. The CD4/CD8 ratio was lower than normal. The same rate was observed in the group over 16 years of age. In the age group of 16 and older adults, the number of CD8 was lower than normal. The number of B cells was reduced in the youngest age group, while the largest group was increased. The number of NK cells was also low in the group over 16 years of age, while in other age groups it was normal or increased. Result: The placebo-lenfocite ratio (PLR) which can be easily obtained when the hemogram is studied can be used as an indicator of the cytokine storm, and the absence of excess CD8 in children may be the reason why the COVID-19 disease causes them to be lighter than adults. Increase in NK cells is also one of the protective mechanisms against this disease.

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