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Peritoneal metastazlı over karsinomu: Yaklaşımın yeniden düşünülmesi
2021
Journal:  
Archives of Clinical and Experimental Medicine
Author:  
Abstract:

Epitelyal tipte over karsinomu (EOK), genellikle ileri evrelerde teşhis edilen bir kanser türüdür. Bugüne kadar, EOC'nin standart tedavisi neoadjuvan veya adjuvan platin ve taksan bazlı sistemik kemoterapi ile kombine edilen cerrahi’dir. EOC'nin tekrarlaması durumunda hipertermik intraoperatif intraperitoneal kemoterapi (HİPEK) düşünülmektedir. HİPEK, over ve apendiks kaynaklı psödomiksoma peritonei tedavisinde altın standart olarak kabul edilmiştir. Son zamanlarda, randomize bir klinik çalışma, HIPEK'in, cerrahi serilerde yumurtalık kanserinin (OK) peritona metastazı (PM) için umut verici bir tedavi seçeneği olduğunu desteklemektedir. HİPEK'in ayrıca primer ve nüks OK'nin PM vakalarında etkili bir tedavi seçeneği olduğu bildirilmektedir. Sonuç olarak, HİPEK tekniğinin standardizasyonu ve optimizasyonu, tedavilere yanıt veren OK’nin PM'si olan hasta alt gruplarının belirlenmesi, kişiselleştirilmiş değerlendirme ve multidisipliner ekip tarafından hali hazırda yürütülen tedavilerin hala yeniden değerlendirilmesi gerekmektedir. Bu derlemede over kanserinin peritona metastazı durumunda standart tedavi yaklaşımı ile birlikte uygulamadaki sistemik tedaviler ve cerrahi ile kombine edilmiş HIPEK tedavi yaklaşımlarının güncellenmesi amaçlanmıştır.

Keywords:

Peritoneal metastatic over carcinoma: re-thinking of the approach
2021
Author:  
Abstract:

Epitelyal type over carcinoma (EOK) is a type of cancer that is often diagnosed in advanced stages. Until now, the standard treatment of EOC is neoadjuvan or adjuvan platinum and tax-based systemic chemotherapy combined surgery. In the case of repeated EOC, hypertermic intraoperative intraperitoneal chemotherapy (HIPEC) is considered. HIPEC, over and apendix are considered the golden standard in the treatment of psodomiksoma peritonei. Recently, a randomized clinical study supports that HIPEK is a hopeful treatment option for ovarian cancer (OK) peritoneal metastasis (PM) in the surgical series. HIPEK is also to be an effective treatment option in PM cases of primary and nick OK. As a result, the standardization and optimization of the HIPEK technique, the identification of the subgroups of patients, which are the PM of OK responding to treatments, the personalized evaluation and the treatment currently carried out by the multidisciplinary team are still needed to be re-evaluated. This collection aims to update the systemic treatments and HIPEK treatment approaches combined with surgery in the case of peritoneal cancer metastasis along with the standard treatment approach.

Keywords:

Ovarian Carcinoma With Peritoneal Metastasis: Rethinking Of Management
2021
Author:  
Abstract:

Epithelial Ovarian Carcinoma (EOC), a type of cancer that is usually diagnosed in advanced stages. To date, standard treatment of EOC is surgery with neoadjuvant or adjuvant platin and taxane based systemic chemotherapy. Hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) is considered in cases of recurrence of EOC. HIPEC has been accepted as a gold standart for the treatment of pseudomyoxoma peritonei of ovarian and appendiceal origin. More recently, a randomized clinical trial supports that HIPEC is a promising treatment option for peritoneal metastasis (PM) of ovarian cancer (OC) in surgical series. HIPEC is also reported to be an effective treatment option in primary and recurrent cancer cases with PM of OC. As a result, the standardization and optimization of the HIPEC technique, determination of patient subgroups with PM of the OC responding to treatments, personalized evaluation and the treatments currently carried out by the multidisciplinary team still need to be re-evaluated. In this review, it is aimed to update the standard treatment approach in case of peritoneal metastasis of ovarian cancer, along with the systemic treatments and HIPEC treatment approaches combined with surgery.

Keywords:

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Archives of Clinical and Experimental Medicine

Field :   Sağlık Bilimleri

Journal Type :   Uluslararası

Metrics
Article : 198
Cite : 10
Archives of Clinical and Experimental Medicine