Abstract:

The aim of this study is to evaluate the relationship between serum amyloid A (SAA) and other inflammatory markers frequently used in clinical practice in patients with Familial Mediterranean Fever (FMF).Ninety patients (38 males, 52 females) with a diagnosis of FMF were included in this study. FMF diagnosis was made according to Tel-Hashomer criteria. The patients were divided into two groups according to their SAA levels. Group 1:high SAA (>6.4 mg/dL), Group 2:normal SAA (≤6.4 mg/dL). The correlation between SAA levels and other inflammatory markers in the groups was evaluated.Of the 90 patients included in the study, 56.7% had SAA value>6.4 mg / dL and 43.3% had ≤6.4 mg/dL. There was no significant difference between the groups in terms of serum creatinine, estimated glomerular filtration rate, uric acid, albumin, leukocyte, lymphocyte and platelet counts and platelet/lymphocyte ratio (PLR). The average fibrinogen, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), neutrophil/lymphocyte ratio (NLR) and CRP/albumin values in group 1 were statistically higher than group 2, and the mean hemoglobin was lower. The mean neutrophil and monocyte count of group 1 was higher than group 2, but this difference was not statistically significant. There was a strong positive correlation between SAA and CRP, moderate positively with ESR and CRP/albumin, and a weak positive correlation between leukocyte count and NLR.Since the CRP level shows the highest correlation with SAA during the attack-free period in FMF patients, it can be used to predict disease activity and subclinical inflammation in cases where SAA levels cannot be evaluated.

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