Abstract:

Objective: In this study, NLR and PLR values of both HELLP syndrome and preeclampsia patients were compared with normal healthy control group. Method: This study was performed retrospectively by scanning the files of 50 HELLP syndrome, 110 severe preeclampsia (PE) and 61 control patients admitted to the Mersin University Medical Faculty Obstetrics and Gynecology Unit between 2012-2020. In the study, patients with HELLP syndrome and preeclampsia were compared with a healthy control group. Patients with additional disease were excluded from the study. Venous blood hemogram parameters of the patient groups and biochemical values obtained during delivery were recorded. Patients' age, gestational week, liver function tests, kidney function tests, hemogram parameters, NLR and PLR values and complications were compared. Ethical consent of the study was obtained (Date of decision: 28/04/2021; Decision number: 343). Results: In the study, the neutrophil count was found to be significantly higher in the HELLP syndrome group compared to the control group (9493 and 7210, respectively, p=0.04). NLR was higher in both HELLP syndrome and PE groups compared to the control group (It was significantly higher in the HELLP syndrome group compared to the control group (5.47 and 3.66, respectively, p = 0.02)). PLR was found to be lower in both the HELLP syndrome and PE groups compared to the control group ((In the HELLP syndrome group, compared to control group (72 and 111.18, respectively, p = 0.0001) and PE group (72 and 107.75, respectively, p= 0.0002) was found to be significantly low)). There was a significant difference in the number of platelets between all groups (in the HELLP syndrome group, it was found to be significantly lower than the PE group (139.181 and 196.222, respectively, p = 0.0002) and the control group (139.181 and 222.639, respectively, p = 0.0001). In addition, it was found to be significantly lower in the PE group compared to the control group (196.222 and 222.639, respectively, p = 0.003). MPV was found to be significantly lower in the HELLP syndrome group compared to the control group (9.95 and 11.13, respectively, p = 0.04). Conclusion: In our study, it was concluded that the increase in NLR and the decrease in PLR and MPV, which are inflammatory markers, can be used both in the diagnosis of HELLP syndrome and in the differentiation of HELLP syndrome and PE. Keywords: HELLP syndrome, Neutrophil- lymphocyte ratio, Mean platelet volume, Preeclampsia, Platelet-lymphocyte ratio.

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