Özet:

INTRODUCTION: The aim of this study was to develop Fluticasone propionate (FP)-loaded solid lipid nanoparticle (SLN) formulations using the factorial design approach. METHODS: Tristearin percentages (X1) (1%, 2% and 4%) and homogenization cycles (X2) (2, 4, 8 cycles) were selected as independent variables in the factorial design. SLN formulations were optimized by multiple regression analysis (MLR) to evaluate the influence of the selected process and formulation independent variables on SLNs characteristics namely as encapsulation efficiency (Q1) and particle size (Q2). Polydispersity index and surface charge of the SLNs were also evaluated in this research. Besides, transmission electron microscopy, Differential scanning calorimetry and in vitro drug relase studies were carried out on the optimum SLN formulation. RESULTS: MLR analysis indicated that as homogenization cycle (X2) increased in the production process, the mean particle size was decreased. DISCUSSION AND CONCLUSION: This research displayed that FP-encapsulated SLNs with desired characteristics can be produced by varied the production and content variables of the formulations.

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