Abstract:

The aim is to keep light on the role of advanced mother age (IAY) in determining the result of complicated pregnancies with SARS-CoV-2 infection. The method of the multinational cohort study included women with SARS-CoV-2 infection certified in laboratory from 76 centers located in 27 different countries in Europe, the United States, South America, Asia and Australia between 4 April 2020 and 28 October 2020. The primary result was the positioning in the intensive care unit, the use of mechanical ventilation (entubation, continuous positive airway pressure need, extracorporeal membrane oxigenization), severe respiratory symptoms (including dyspnea and respiratory impairment) or the compound measurement of maternal mortality and morbidity, including death. The findings were included in the study, 887 pregnancies with positive SARS-CoV-2 results with RT-PCR (transcriptase polymerase chain reaction) in nasal and pharyngal scratch samples (235 cases with an early mother's age and 652 cases without an early mother's age). The risk of complicated adverse maternal result was higher in the IAY group (95% CU 1.4-2.9; p=0.002) with 1.99 OR (probability ratio) compared to the group under 35 years of age. Similarly, women over the age of 35 were at a higher risk of hospitalization (OR: 1.88, 95% GA 1.4-2.5; p<0.001), severe respiratory symptoms (OR: 1.53, 95% GA 1.0-2.3; p=0.04) and/or infection (OR: 2.00, 95% GA 1.1-3.7; p=0.003) but there was no difference in perinatal result risk. Advanced mother age is an independent risk factor for adverse maternal result in complicated pregnancies with SARS-CoV-2 infection. To improve the maternal result, the correct risk classification is necessary in women suspected of SARS-CoV-2 infection during pregnancy in order to identify the subgroup of women who can benefit from a personalized management, including elective hospitalization and/or long-term follow-up.

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