Abstract:

Objective: Inadequate control of glycemia in diabetic patients is the primary cause of both micro- and macrovascular complications. Several components of complete blood count were investigated and have found to be higher in diabetic patients. We aimed to evaluate white blood cell (WBC), neutrophil, lymphocyte and platelet counts and, red cell distribution width (RDW), mean platelet volume (MPV) and platelet distribution width (PDW) in type 2 diabetes mellitus (T2DM) patients with inappropriorate glycemic management (HbAlc >7%) despite using insulin therapy. Methods: 135 type 2 diabetic patients with inappropriorate blood glucose management (HbAlc value >7 %) despite using insulin therapy for at least 3-month period (only insulin or insulin plus oral hypoglycemic agents) and 121 healthy subjects were included in the study. Demographic, anthropometric and laboratory data were recorded. Results: WBC, neutrophil, lymphocyte and monocyte counts were higher in DM group (p<0.0001). WBC counts were positively correlated with diastolic blood pressure (DBP), body mass index (BMI), waist circumference (WC) and high-sensitive C- reactive protein (hsCRP), fasting plasma glucose (FPG), post-prandial glucose (PPG), HbA1c and triglyceride levels (p<0.05). Neutrophil counts were positively correlated with hsCRP, FPG, HbA1c, BMI, PPG, LDL-Cholesterol (LDL-C) and microalbumin levels (p<0.05). Lymphocyte counts were positively correlated with systolic blood pressure (SBP), DBP, BMI, WC and FPG, HbA1c, LDL-C and triglyceride levels (p<0.05). WBC, neutrophil and lymphocyte counts were negatively correlated with HDL-Cholesterol (HDL-C) levels (p<0.05). PDW was higher in DM group (16.65±0.59 to 16.51±0.51, p:0.043). PDW was positively correlated with age, DBP, FPG, PPG, HbA1c, LDL-C and triglyceride levels (p<0.05). Monocyte to HDL-C ratio was higher in DM group (13.50 ± 5.34 to 10.54 ± 4.29, p<0.0001). Conclusions: In this study white blood cell, neutrophil and lymphocyte counts and PDW were higher in type 2 diabetic patients with inappropriorate glycemic management despite insulin therapy and they were correlated wıth cardio-metabolic risk factors. Leukocyte subtypes and PDW may be used as a marker for cardiovascular diseases in these patients.

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