Abstract:

Objective: The pathophysiology of carotid artery stenosis (CAD) is not fully understood. Research has showed that mean platelet volume (MPV) is a potential marker for platelet activation and is a key factor in atherosclerosis pathophysiology. Recently, the ratio of monocyte count to HDL (MHR) has been identified as a predictor of cardiovascular events in patients. In the light of these findings, the goal of study was to evaluate the potential association of MPV and MHR with the severity of CAD. Material-Method: Patients had divided into three groups: CAD≥ 60% (40 patients), CAD <60% (40 patients) and no carotid atherosclerotic disease (40 individuals). Patients' demographic characteristics, clinical features and laboratory findings were compared between groups. Results: MPV and MHR leves were lower in the control group than CAD <60 group and lower in CAD <60 group than CAD ≥60 group (p <0.001, p <0.001). Higher MPV (OR= 6.050; 95% CI: 2.946-12.427; p <0.001) and MHR (OR= 1.107; 95% CI: 1.045-1.159; p <0.001) levels were detected as independent predictor for ≥60% carotid artery stenosis after multiple linear regression analysis. In the correlation analysis, a positive correlation was found between MPV and the rate of carotid artery stenosis (p<0.001, r=0.680). Conclusion: In our study, a potential relationship between MPV and MHR with carotid artery disease was determined. Our study may make contributions to understanding the carotid artery atherosclerosis pathophysiology and developing treatments for it.

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