Abstract:

Background: Seborrheic dermatitis is characterized by chronic inflammation affecting seborrheic areas. Many factors are responsible for the etiology of disease. Fatty acids play a role in protecting skin structural integrity and functionality. Essential fatty acids and unsaturated fatty acids have a regulatory effect on inflammation.Objectives: In this study, it was aimed to evaluate fatty acid profile in patients with seborrheic dermatitis in the active phase of disease. Thirty seborrheic dermatitis patients with active lesions and 30 healthy controls were included in study. Fatty acid analysis was performed on the serum using 7890/5970c gas chromatography-mass spectrometry (GC/MS) instrument (Agilent, Santa Clara, USA). The percentage of myristic acid, palmitic acid, stearic acid, palmitoleic acid, oleic acid, linoleic acid, linolenic acid and arachidonic acid levels in general fatty acids was determined. In patients with seborrheic dermatitis, essential and unsaturated fatty acids were found to be significantly lower than healthy controls (p <0.001, p <0.001, respectively). Providing normal levels of essential and unsaturated fatty acids in patients with seborrheic dermatitis will contribute to treatment of disease and maintenance of health.

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